Flt3L in Combination With HSV1-TK-mediated Gene Therapy Reverses Brain Tumor–induced Behavioral Deficits
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چکیده
منابع مشابه
HSV1-tk gene expression imaging agents
In this study, we synthesized Tc(CO)3-2 0-aminomethylpyridyl-20-deoxyuridine (Tc(CO)3-AMPDU) and Tc(CO)3-aminoethylpyridyl-20-deoxyuridine (Tc(CO)3-AEPDU) as potential agents for imaging the expression of the non-invasive herpes simplex virus type-1 thymidine kinase. AMPDU and AEPDU were synthesized from uridine in five chemical steps and then labeled with [Tc(CO)3(H2O)3] + (370MBq/0.5mL) at 10...
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In spite of preclinical efficacy and recent randomized, controlled studies with adenoviral vectors expressing herpes simplex virus-1 thymidine kinase (HSV1-TK) showing statistically significant increases in survival, most clinical trials using single therapies have failed to provide major therapeutic breakthroughs. Because glioma is a disease with dismal prognosis and rapid progression, it is a...
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__________________________________________________________________________________________________ Correspondence: Naoto Adachi, MD&PhD. Department of Neurosurgery, Yamaguchi University School of Medicine, MinamiKogushi 1-1-1, Ube, Yamaguchi 755-8505, Japan. Tel +81-836-22-2295; Fax +81-836-22-2294; E-mail [email protected] Abbreviations: HSV-TK, herpes simplex virus thymidine kin...
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ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2008
ISSN: 1525-0016
DOI: 10.1038/mt.2008.18